Southwark Council is set to approve plans for a 41 storey tower despite objections from the neighbouring Ministry of Sound nightclub.
Planning officers at the council are recommending that councillors approve the scheme at a meeting next week.
The nightclub believes that noise from its operation could result in a noise abatement order if residents of the proposed flat were to complain, but the council officer’s report dismissed this concern.
It said: “Even when MoS is not operating this particular location is such that noise levels from trains and road traffic would also result in the need to keep windows closed at night in order for noise standards to be met.
“To succeed in any action in nuisance a future resident would have to establish that the average person would expect to be able to sleep without disturbance with his window open in this inner city London location.
“Officers consider that it is reasonable to conclude that there may be real difficulty in establishing this.”
The scheme would comprise 255 private flats, 80 intermediate flats, 4,785sq metres of offices, educational and health uses.
A planning agreement would see the developer pay more than £4 million to fund transport, education, public realm and other improvements.
A new website for the local community, which explains the council's plans for the regeneration of Old Kent Road, has been launched