Cathedrals ward is to see 60 homes built and 800sq m of office space created on a site which was formerly part of Lewisham Southwark College campus.
In May 2016, Southwark Council granted planning permission to an application by the Acorn Group for a 0.4 ha site on Ufford Street, 500m from Waterloo station.
Former college buildings on the site will be demolished to make room for two apartment blocks of five and seven storeys, located to the south of a new college building which is nearing completion.
A new public pedestrian street will link the development to The Cut to the north, and public open space will be created between the buildings.
An art gallery dedicated to science has launched its first exhibition after opening in September.